Order Trazodone tablets online in the USA (prescription required)

Product Name	Trazodone
Dosage	50 mg, 100 mg, 150 mg, 300 mg (IR and ER tablets)
Active Ingredient	Trazodone hydrochloride
Form	Oral Tablets (Immediate-Release and Extended-Release)
Description	FDA-approved antidepressant for major depressive disorder; sometimes used off-label for insomnia and anxiety-related sleep disturbances. Not habit-forming; causes sedation in many patients.
How to Order Without Prescription	In the USA, a valid prescription from a licensed clinician is required to purchase trazodone. Use only state-licensed pharmacies or verified mail-order services.

Trazodone is a prescription medicine widely used in the United States for the treatment of major depressive disorder (MDD). Belonging to the pharmacologic class known as serotonin antagonists and reuptake inhibitors (SARIs), trazodone modulates several neurochemical pathways, which helps improve mood, reduce anxiety associated with depression, and promote restorative sleep. In the U.S. market, it is available primarily as generic trazodone hydrochloride in immediate-release (IR) and extended-release (ER) tablets. Common strengths include 50 mg, 100 mg, 150 mg, and 300 mg.

Because trazodone can cause drowsiness, many clinicians leverage that effect when nighttime insomnia accompanies depression. Although it is not FDA-approved specifically for insomnia, trazodone is one of the most frequently prescribed off-label sleep aids in adults. In all cases, a U.S.-licensed prescriber must determine whether trazodone is appropriate for you and provide a prescription. U.S. pharmacies dispense the medication once a valid prescription is on file, either in-store or via mail-order.

Trazodone cost and pricing in the USA

In the United States, trazodone is widely available as an affordable generic medication. Prices vary by strength, formulation (IR vs ER), quantity, insurance coverage, and dispensing pharmacy. As a general guide, immediate-release tablets are typically less expensive per dose than extended-release tablets. Patients often pay lower out-of-pocket costs when using discount programs, manufacturer-independent coupons, or when obtaining 90-day supplies through mail-order services connected to their insurance plans.

Without insurance, many community pharmacies offer competitive cash pricing on the 50 mg and 100 mg tablets, which are the most frequently dispensed strengths. Extended-release (often 150 mg or 300 mg) may carry a higher price because of the formulation technology and fewer manufacturers. Your total monthly cost also depends on your prescribed daily dose. For example, some people take 50–100 mg once nightly, while others using trazodone for depression may require divided doses totaling 150–300 mg/day or more, which changes the number of tablets used per month.

Insurance coverage in the USA commonly includes generic trazodone on preferred tiers, making copays low for many plans. If you are uninsured, consider comparing prices at several pharmacies and exploring reputable coupon services. Pharmacists can also help identify cost-saving strategies, such as switching to a different strength to minimize tablet counts or using a 90‑day prescription to reduce dispensing fees. Never split extended-release tablets; if cost is a concern, ask your prescriber whether an immediate-release regimen could be appropriate for you.

Prices can fluctuate regionally and over time. The most reliable approach is to: (1) confirm your prescribed dose and formulation, (2) check your insurance formulary or discount options, and (3) request a price quote from two or three local and mail-order pharmacies before you fill your script. Your prescriber may adjust the regimen to balance therapeutic goals with affordability.

Note: All purchases of trazodone in the USA require a prescription. Be wary of any source claiming to sell prescription-only medication without a valid U.S. prescription—this is not compliant with federal and state laws and may expose you to unsafe or counterfeit products.

Where can I buy Trazodone in the USA?

 You can fill a trazodone prescription at most U.S. retail pharmacies, supermarket pharmacies, independent community pharmacies, and licensed mail-order pharmacies. Many clinicians offer telehealth appointments, which can be convenient if you are establishing care for depression or adjusting treatment. After a licensed U.S. clinician issues a prescription, you may choose an in-person pickup or have medication delivered to your home by a verified mail-order pharmacy.

When buying online, protect yourself by using pharmacies that are licensed in your state and display appropriate verification seals. The National Association of Boards of Pharmacy (NABP) provides resources to identify legitimate online pharmacies. Look for clear contact information, a physical U.S. address, licensed pharmacists available for consultation, and a requirement for a valid prescription.

Our goal is to support safe access and education. If you use an online service, ensure that it follows U.S. regulations, processes prescriptions correctly, and provides FDA-approved or FDA-authorized products. When in doubt, ask your pharmacist or physician to confirm the legitimacy of a website before placing an order.

Delivery timelines vary by pharmacy and shipping method, but most verified U.S. mail-order pharmacies provide tracking and offer auto-refill options to help you avoid running out of medication.

Trazodone in the United States

Trazodone is not a controlled substance in the USA, but it is prescription-only. IR tablets are typically taken more than once daily for depression, while ER tablets are designed for once-daily bedtime dosing. Because tolerability and sedative effects differ among individuals, follow your prescriber’s instructions carefully and do not adjust the dose on your own.

What is trazodone?

 Trazodone hydrochloride is an antidepressant classified as a serotonin 5‑HT2 receptor antagonist and serotonin reuptake inhibitor (SARI). It was first introduced decades ago and remains widely used due to its unique combination of antidepressant action and sedating properties. In clinical practice, trazodone can improve mood, reduce anxiety-related symptoms in depression, and help with sleep onset and maintenance when insomnia coexists with mood disorders.

Unlike selective serotonin reuptake inhibitors (SSRIs), trazodone exerts multi-receptor effects. It antagonizes 5‑HT2A/5‑HT2C receptors, weakly inhibits serotonin reuptake, and blocks histamine H1 and alpha‑1 adrenergic receptors—actions that contribute to its sedating and hypotensive effects. These properties explain both its therapeutic benefits (especially for sleep in some patients) and its side effect profile (e.g., drowsiness, dizziness, orthostatic hypotension).

Trazodone is FDA-approved for major depressive disorder in adults. It is often prescribed off-label for insomnia at lower doses, typically taken at bedtime. Off-label use should be guided by a clinician who weighs potential benefits against risks and monitors response and tolerability.

Brand-name versions have historically included Desyrel and the extended-release formulation Oleptro; however, most patients today receive generic trazodone, which the FDA considers therapeutically equivalent to brand products.

Trazodone for insomnia (off-label use)

 Many U.S. clinicians consider trazodone when adults experience sleep disorders, particularly insomnia related to depression or anxiety. Lower doses (e.g., 25–100 mg at bedtime) are commonly used off-label to leverage trazodone’s sedating effects. Studies suggest benefit for sleep continuity and maintenance, though the evidence base is mixed and more robust data are needed for long-term use.

Because trazodone is not a controlled medication and is generally non-habit-forming, some prescribers prefer it over certain hypnotics for select patients. Still, it is not risk-free: daytime drowsiness, dizziness, and orthostatic hypotension may occur, especially after dose increases or in older adults. If trazodone is used for sleep, the goal is to use the lowest effective dose for the shortest necessary duration while addressing the root causes of insomnia (e.g., mood disorder, sleep hygiene, comorbid medical conditions).

Behavioral strategies (consistent sleep schedule, limiting caffeine/alcohol late in the day, reducing screen time before bed) and cognitive behavioral therapy for insomnia (CBT‑I) remain first-line approaches. If medication is needed, your clinician will tailor therapy to your health history, potential drug interactions, and personal preferences.

Important: Doses and schedules for insomnia differ from those for depression. Do not change how you take trazodone without speaking with your prescriber.

The role of trazodone in depression and sleep

Depression and poor sleep often reinforce each other. Trazodone’s pharmacology allows it to be used as a single agent for depression that also provides nighttime sedation. In other cases, it may be combined with another antidepressant to support sleep while the primary antidepressant treats core mood symptoms. If used in combination, clinicians carefully monitor for additive side effects and signs of serotonin syndrome.

Boxed warning: suicidality and antidepressants

 Like other antidepressants, trazodone carries a U.S. FDA Boxed Warning for increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults, particularly during the initial months of therapy and during dose changes. Trazodone is not approved for use in pediatric patients for depression. Adults of any age should be monitored closely for clinical worsening, suicidality, or unusual changes in behavior, especially at the start of treatment or after dose adjustments. Families and caregivers should be advised to observe and report concerning symptoms promptly.

How trazodone works in the brain

Trazodone antagonizes postsynaptic 5‑HT2A/2C receptors, which is thought to mitigate anxiety and insomnia, and it weakly inhibits the serotonin transporter, increasing synaptic serotonin. Antagonism at histamine H1 and alpha‑1 adrenergic receptors contributes to sedation and potential orthostatic hypotension. The net effect is a rebalancing of neurotransmission involved in mood regulation and sleep architecture. As with most antidepressants, full antidepressant effects may take several weeks to emerge.

Trazodone for anxiety (off-label)

 Although not FDA-approved for generalized anxiety disorder or panic disorder, trazodone’s calming and sedating properties make it a pragmatic option in select cases, particularly when anxiety coexists with depression and poor sleep. If anxiety is your primary symptom, your clinician may consider first-line therapies (e.g., SSRIs, SNRIs, CBT) and evaluate whether trazodone is an appropriate adjunct.

Trazodone in older adults

 Older adults can be more sensitive to trazodone’s sedative and blood pressure–lowering effects, which may increase the risk of falls, dizziness, and confusion. When used, clinicians typically start at the lowest effective dose, monitor closely, and reassess regularly. Because older adults often take multiple medications, screening for drug interactions is essential. Non-pharmacologic sleep strategies should be prioritized whenever possible, and lighting modifications or assistive devices can reduce fall risk at night.

Mechanism of action

 Trazodone’s mechanism reflects a combination of receptor antagonism and transporter modulation:

- 5‑HT2A/2C antagonism: reduces anxiety, improves sleep continuity.
- Serotonin transporter inhibition: modestly increases serotonin availability and supports mood improvements.
- H1 histamine antagonism: contributes to sedation, especially at lower doses.
- Alpha‑1 adrenergic blockade: may cause dizziness and orthostatic hypotension; caution when standing quickly.

Safety and tolerability

Millions of Americans have been treated with trazodone. Most side effects are mild to moderate and dose-related. Common issues include drowsiness, dizziness, dry mouth, headache, nausea, constipation, and blurred vision. Rare but serious adverse events include serotonin syndrome, cardiac rhythm disturbances (including QT prolongation in susceptible individuals), severe hypotension, and priapism (a prolonged, painful erection) which requires emergency care.

Trazodone dosage and administration

 Your dose depends on your condition, age, comorbidities, and concomitant medications. Follow your prescriber’s instructions exactly.

Immediate-release (IR) tablets for depression: Typical initial dosing is 150 mg per day in divided doses (for example, 50 mg three times daily), with increases of 50 mg/day every few days as tolerated. Outpatients often require 150–300 mg/day; some may benefit from nighttime dose consolidation due to sedation. The maximum daily dose for outpatients is generally 400 mg/day; hospitalized patients may receive up to 600 mg/day in divided doses.

Extended-release (ER) tablets: Commonly initiated at 150 mg once nightly. Dose may be increased by 75 mg to 150 mg increments, typically not exceeding 375 mg/day. Swallow ER tablets whole—do not crush, split, or chew.

Off-label insomnia: Lower doses (e.g., 25–100 mg at bedtime) are often used. Because evidence is evolving, clinicians periodically reassess the need for ongoing therapy and consider non-drug approaches.

Administration tips: Many patients tolerate IR tablets better when taken shortly after a meal or a snack to minimize dizziness or nausea. Be consistent with how you take ER tablets (usually at bedtime). Avoid alcohol and use caution with other sedatives.

Switching, tapering, and discontinuation

 If you and your clinician decide to stop trazodone, a gradual dose reduction helps minimize discontinuation symptoms such as sleep disturbance, irritability, or anxiety. The taper schedule is individualized based on dose, duration of use, and clinical response. Do not discontinue abruptly unless your clinician instructs you to do so for safety reasons.

Missed dose and overdose

If you miss a dose and it is close to your next scheduled time, skip the missed dose and resume your regular dosing schedule. Do not double up. For nighttime dosing, taking the missed dose too late may cause next-day drowsiness.

Overdose symptoms can include severe drowsiness, dizziness, vomiting, low blood pressure, abnormal heart rhythm, seizures, and in rare cases, complications like serotonin syndrome or priapism. In case of suspected overdose, call 911 or seek emergency medical attention immediately. For poison control guidance in the USA, contact 1-800-222-1222.

Contraindications and precautions

Trazodone is contraindicated in patients who are taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping an MAOI (including linezolid or intravenous methylene blue due to MAO-inhibiting properties). Concomitant use increases the risk of serotonin syndrome. Do not start trazodone while using an MAOI; consult your clinician for a safe washout period.

Use caution in individuals with a history of cardiac disease (recent myocardial infarction, arrhythmias, or risk for QT prolongation), hypotension, syncope, angle-closure glaucoma, bipolar disorder (risk of mood switch), bleeding risk (especially with anticoagulants/antiplatelets), seizures, severe hepatic or renal impairment, and in those predisposed to hyponatremia (e.g., older adults, patients on diuretics). Report any signs of mania, agitation, confusion, or worsening depression promptly.

Patient use instructions

 Take trazodone exactly as prescribed. Do not exceed the recommended dose or frequency. If your regimen includes divided doses, adhere to the schedule to maintain even therapeutic levels and reduce side effects. If you experience morning grogginess, dizziness when standing, or unusual daytime sleepiness, notify your clinician—dose timing or amount may need adjustment.

Avoid driving, operating machinery, or performing tasks that require full alertness until you know how trazodone affects you. Limit alcohol and discuss any use of cannabis or other sedatives with your prescriber, as additive effects can be dangerous.

For ER tablets, swallow whole with water; do not split or crush. For IR tablets, your clinician might allow splitting on the score line if needed for dose adjustments.

Pregnancy and breastfeeding

Data in pregnancy are limited. Decisions about using trazodone during pregnancy require a case-by-case assessment of the benefits of treating maternal depression versus potential fetal risks. Untreated depression carries significant risks for both parent and fetus, so discuss all options thoroughly with your obstetrician and mental health provider.

Trazodone is excreted into human breast milk in small amounts. Consider the benefits of breastfeeding, the mother’s clinical need for trazodone, and potential adverse effects on the breastfed infant. Monitor infants for sedation, feeding difficulties, or irritability. When possible, dosing immediately after a feeding and using the lowest effective dose may reduce exposure.

Pharmacist’s tips for taking trazodone

 Start low and go slow: Sedation and dizziness are dose-related, so gradual titration helps your body adjust.

Consistent timing matters: If using trazodone for sleep, take it at the same time nightly. For depression with divided dosing, follow your schedule precisely.

Stand up slowly: To reduce lightheadedness and risk of falls, especially at night, rise gradually from sitting or lying positions.

Watch for interactions: Always inform your pharmacist about all medicines and supplements you take, including over-the-counter products and herbal remedies like St. John’s wort.

Do not stop abruptly: Work with your prescriber on a taper if discontinuation is appropriate.

Safety Precautions

 Do not use trazodone if you are allergic to it or any component of the formulation.

Avoid alcohol and use caution with other central nervous system depressants; combined effects can be dangerous.

Use particular caution if you have severe heart disease, are prone to fainting, have glaucoma, or are at risk for electrolyte disturbances (e.g., low potassium or magnesium), which can predispose to arrhythmias.

Trazodone side effects

 Not everyone experiences side effects, and many resolve with continued use or dose adjustments. Contact your clinician if symptoms are severe, persistent, or concerning.

Common side effects: drowsiness, dizziness, dry mouth, headache, nausea, constipation, nervousness, blurred vision, fatigue, and orthostatic hypotension. Some people experience vivid dreams or mild confusion when first starting therapy.

Serious side effects (seek medical help): signs of serotonin syndrome (agitation, hallucinations, rapid heartbeat, sweating, shivering, muscle stiffness, nausea/vomiting/diarrhea), irregular heartbeat or fainting, severe dizziness, allergic reactions (rash, hives, trouble breathing), significant mood changes or suicidal thoughts, prolonged or painful erection (priapism), severe low sodium (confusion, seizures), or signs of liver problems (dark urine, severe fatigue, jaundice).

Adverse effects by system

Central nervous system:

• somnolence, sedation, dizziness, headache
• confusion (more likely in older adults at higher doses)
• tremor or agitation (rare); serotonin syndrome with interacting drugs

Gastrointestinal:

• nausea, constipation, dry mouth
• abdominal discomfort; rare liver enzyme elevations

Cardiovascular:

• orthostatic hypotension, syncope
• palpitations; rare QT prolongation or arrhythmias (risk increased in predisposed patients)

Genitourinary/Endocrine:

• priapism (rare; medical emergency)
• sexual dysfunction (reduced libido, erectile difficulties)

Hematologic/Metabolic:

• hyponatremia due to SIADH (rare; more common in older adults)
• abnormal bleeding risk, especially with anticoagulants/antiplatelets

Ophthalmic:

• blurred vision; potential angle-closure glaucoma in susceptible individuals

Reporting side effects

 If you experience adverse effects, contact your clinician or pharmacist. In the USA, you can also report side effects to FDA MedWatch at 1‑800‑FDA‑1088 or online at www.fda.gov/medwatch.

Interaction of trazodone with other medicines

 Trazodone can interact with prescription and over-the-counter medicines, vitamins, and herbal supplements. Always provide a complete medication list to your healthcare team. Interactions may increase side effects or reduce effectiveness. Your clinician can adjust therapy or monitor more closely when combinations are necessary.

High‑concern interactions include:

• MAOIs (phenelzine, tranylcypromine), linezolid, or methylene blue (IV): risk of severe serotonin syndrome—contraindicated
• Other serotonergic agents: SSRIs, SNRIs, buspirone, triptans, tramadol, lithium, St. John’s wort—monitor for serotonin syndrome
• CYP3A4 inhibitors: ketoconazole, itraconazole, ritonavir, clarithromycin, grapefruit juice—may increase trazodone levels; dose adjustments/monitoring may be needed
• CYP3A4 inducers: carbamazepine, phenytoin, rifampin, St. John’s wort—may decrease trazodone levels, reducing efficacy
• CNS depressants: benzodiazepines (e.g., clonazepam, lorazepam), sedative-hypnotics, opioids, alcohol—additive sedation and respiratory depression risk
• Drugs affecting cardiac rhythm: certain antipsychotics, macrolide antibiotics, fluoroquinolones, class IA/III antiarrhythmics—caution in patients with QT risk
• Anticoagulants/antiplatelets (e.g., warfarin, clopidogrel, NSAIDs): potential increased bleeding risk

This list is not exhaustive. Maintain an updated medication list and share it with your prescriber and pharmacist at each visit to minimize interaction risks.

Recommendations from our specialists

 If you and your clinician are considering trazodone, discuss your goals: mood improvement, sleep support, or both. Review your medical history, current medications, and daily routines to select the most appropriate formulation and dosing schedule. For many adults, starting at a low dose and titrating gradually enhances tolerability. Incorporating non-drug strategies—therapy, sleep hygiene, exercise, and social support—often improves overall outcomes.

Use only state-licensed U.S. pharmacies or verified mail-order services to fill prescriptions. A valid prescription is required nationwide. If you experience side effects, don’t stop the medication abruptly; contact your prescriber to adjust your plan safely.

Ready to begin treatment? Talk to a U.S.-licensed clinician about Trazodone

When appropriate, trazodone can be a practical option for managing depression with coexisting sleep disturbance. After a clinician evaluates your needs, you can fill your prescription at a licensed U.S. pharmacy and, in many cases, choose home delivery for convenience.

• Prescription required in the USA — consult a licensed healthcare provider
• Fast, discreet delivery available through legitimate U.S. mail‑order pharmacies
• FDA‑approved generics from reputable manufacturers
• Cost‑saving options including insurance, coupons, and 90‑day supplies
• Pharmacist support to help you use your medication safely and effectively

Join the many patients who have successfully integrated trazodone into their comprehensive care plans. Your health team is ready to help you take the next step safely and confidently.

Buy Trazodone Now